The border regions of the Russian Far East have historical trade links with the Chinese province of Heilongjiang. The evaluation of joint economic projects between these regions is of great importance for the development of cross-border trade between them. The peculiarity of cooperation is related to the each region of the Russian Federation development, their history, specialization, and demography, social, cultural and national traditions. One of the areas of cross-border trade relations is special economic zones, on the territory of which there is a special mode of entrepreneurship. Cross-border trade influences integration processes, which increases the volume of foreign trade exchange and improves regional proportions. Co-development programs have become a new form of cross-border cooperation in the far East. The new forms of cooperation have been established since 2009: more active development of trade infrastructure, credit and trade cooperation. Several periods in trade and economic relations between the Far East and the Chinese province of Heilongjiang can be highlighted. This distinction is reflected in the works of Russian investigators: M. V. Alexandrova, D. V. Suslov, L. A. Ponkratova, S. A. Ivanov, N. L. Simutina, N. P. Ryzhakov, and Chinese scientists Zhao Xin and Huang Meiliang. We can draw the following conclusions based on these studies: there is a transition in the foreign trade of the Russian Federation entitiess in the far East with the Chinese province of Heilongjiang from an asymmetric dependence to an agreement on national strategies for the development of the far Eastern Russian border and the North-East of the People's Republic of China.